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Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in CFH Y402H Patient-Derived Choriocapillaris Endothelial Cells

2026-07-31

Abstract excerpt

<title>Abstract</title> <p> Age-related macular degeneration (AMD) is a leading cause of central vision loss. Immunofluorescence and gene expression studies in human donor eyes have shown that choriocapillaris endothelial cells (CECs) are lost before retinal pigment epithelium (RPE) degeneration, leaving extracellular matrix–filled empty lumens known as "ghost vessels." To investigate disease mechanisms, we gene...

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Literature Corpus work
178d3e3c-f0e7-5865-a86f-861bf813a247
DOI
10.21203/rs.3.rs-10140072/v1
Open publication

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Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in CFH Y402H Patient-Derived Choriocapillaris Endothelial CellsDOI 10.21203/rs.3.rs-10140072/v1
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