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Article

CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex

25 Sept 2019

Abstract excerpt

Age Related Macular Degeneration (AMD) is the first cause of social blindness in people aged over 65 leading to atrophy of retinal pigment epithelial cells (RPE), photoreceptors and choroids, eventually associated with choroidal neovascularization. Accumulation of undigested cellular debris within RPE cells or under the RPE (Drusen), oxidative stress and inflammatory mediators contribute to the RPE cell death....

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PMID: 31554875
DOI: 10.1038/s41598-019-50420-9

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