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Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in <i>CFH</i> Y402H Patient-Derived Choriocapillaris Endothelial Cells

2026-06-19

Abstract excerpt

Age-related macular degeneration (AMD) is a leading cause of central vision loss. Immunofluorescence and gene expression studies in human donor eyes have shown that choriocapillaris endothelial cells (CECs) are lost before retinal pigment epithelium (RPE) degeneration, leaving extracellular matrix–filled empty lumens known as “ghost vessels.” To investigate disease mechanisms, we generated CECs from patient-specif...

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Literature Corpus work
234f9f36-fd50-5be8-9d29-e3a539a8e82e
DOI
10.64898/2026.06.18.733111
Open publication

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Oxidative Stress Susceptibility, Complement Dysregulation, and Metabolic Reprogramming in <i>CFH</i> Y402H Patient-Derived Choriocapillaris Endothelial CellsDOI 10.64898/2026.06.18.733111
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