Article
Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology.
Nature communications - 18 Oct 2024
Maharjan Sunita, Gamper Howard, Yamaki Yuka, Christian Thomas, Henley Robert Y, Li Nan-Sheng, Suzuki Takeo, Suzuki Tsutomu, Piccirilli Joseph A, Wanunu Meni, Seifert Erin, Wallace Douglas C, Hou Ya-Ming
Abstract excerpt
Human mitochondrial tRNAs (mt-tRNAs), critical for mitochondrial biogenesis, are frequently associated with pathogenic mutations. These mt-tRNAs have unusual sequence motifs and require post-transcriptional modifications to stabilize their fragile structures. However, whether a modification that stabilizes a wild-type (WT) mt-tRNA would also stabilize its pathogenic variants is unknown. Here we show that the...
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