Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.

Nucleic acids research - 27 Nov 2024

Lu Jia-Li, Dai Yichen, Ji Kunqian, Peng Gui-Xin, Li Hong, Yan Chuanzhu, Shen Bin, Zhou Xiao-Long

Abstract excerpt

Escherichia coli MnmE and MnmG form a complex (EcMnmEG), generating transfer RNA (tRNA) 5-carboxymethylaminomethyluridine (cmnm5U) modification. Both cmnm5U and equivalent 5-taurinomethyluridine (τm5U, catalyzed by homologous GTPBP3 and MTO1) are found at U34 in several human mitochondrial tRNAs (hmtRNAs). Certain mitochondrial DNA (mtDNA) mutations, including m.3243A > G in tRNALeu(UUR) and m.8344A > G in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Escherichia coli Proteins
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Diseases

Share to RNA, Mitochondrial

Share to RNA, Transfer

Share to Taurine

Share to Uridine

Source

Open in PubMed Open full text

Identifiers

PMID: 39380483
DOI: 10.1093/nar/gkae854
PMCID: PMC11602126

Genes

GTPBP3
MTO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.PMID 39380483Read ↗

Restoration of mitochondrial function through activation of hypomodified tRNAs with pathogenic mutations associated with mitochondrial diseases.Semantic proximity Read ↗

Mitochondrial tRNA modifications: functions, diseases caused by their loss, and treatment strategies.Semantic proximity Read ↗

The human tRNA taurine modification enzyme GTPBP3 is an active GTPase linked to mitochondrial diseases.Semantic proximity Read ↗

Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation.Semantic proximity Read ↗

Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase PSemantic proximity Read ↗

[Nucleotide modification of mitochondrial tRNA and mitochondrial diseases].Semantic proximity Read ↗

Post-transcriptional methylation of mitochondrial-tRNA differentially contributes to mitochondrial pathology.Semantic proximity Read ↗

Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases.Semantic proximity Read ↗

Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial PathologySemantic proximity Read ↗

Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P.Semantic proximity Read ↗

Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases.Semantic proximity Read ↗

TRMT2B is responsible for both tRNA and rRNA m <sup>5</sup> U-methylation in human mitochondriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.