Article
Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR).
Nucleic acids research - 1 Feb 1999
Helm M, Florentz C, Chomyn A, Attardi G
Abstract excerpt
Post-transcriptional modifications are characteristic features of tRNAs and have been shown in a number of cases to influence both their structural and functional properties, including structure stabilization, amino-acylation and codon recognition. We have developed an approach which allows the i...
Topics
- Autoradiography
- Base Sequence
- Cell Line
- Chromatography, Thin Layer
- DNA, Mitochondrial
- Humans
- MELAS Syndrome
- MERRF Syndrome
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Processing, Post-Translational
- RNA, Transfer, Leu
- RNA, Transfer, Lys