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Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants.

Immunity - 12 Dec 2023

Korenkov Michael, Zehner Matthias, Cohen-Dvashi Hadas, Borenstein-Katz Aliza, Kottege Lisa, Janicki Hanna, Vanshylla Kanika, Weber Timm, Gruell Henning, Koch Manuel, Diskin Ron, Kreer Christoph, Klein Florian

Abstract excerpt

Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies carry no or only a few mutations, leaving the question of how ongoing SHM affects neutralization unclear. Here, we reverted variable region mutations of 92 antibodies and tested their impact on SARS-CoV-2 binding and neutralization. Reverting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38035879
DOI: 10.1016/j.immuni.2023.11.004

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