Article

Evidence that chronic lymphocytic leukemia arises from a multiclonal selection process

2024-02-12

Abstract excerpt

<title>Abstract</title> <p>Although chronic lymphocytic leukemia (CLL) is diagnosed by identifying in a patient’s blood a B-cell clone that exceeds 5x10<sup>6</sup>/µL, additional clones have on occasion been identified. To characterize such clones in patients with CLL, we analyzed by NGS the IGHV-IGHD-IGHJ gene rearrangements in circulating CD5<sup>+</sup> B cells from 57 untreated patients. In every patient, we...

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Literature Corpus work: 5cc8e3f5-8bfe-5fcc-b6b8-3de2e1fa8a96
DOI: 10.21203/rs.3.rs-3934299/v1

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