Article
High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease.
Blood - 3 Jun 2010
Palacios Florencia, Moreno Pilar, Morande Pablo, Abreu Cecilia, Correa Agustín, Porro Valentina, Landoni Ana Ines, Gabus Raul, Giordano Mirta, Dighiero Guillermo, Pritsch Otto, Oppezzo Pablo
Abstract excerpt
Interaction of chronic lymphocytic leukemia (CLL) B cells with tissue microenvironment has been suggested to favor disease progression by promoting malignant B-cell growth. Previous work has shown expression in peripheral blood (PB) of CLL B cells of activation-induced cytidine deaminase (AID) among CLL patients with an unmutated (UM) profile of immunoglobulin genes and with ongoing class switch recombination...
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