Article

PROX1 inhibits PDGF-B expression to prevent myxomatous degeneration of heart valves

2023-05-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cardiac valve disease (CVD) is observed in 2.5% of the general population and 10% of the elderly people. Effective pharmacological treatments are currently not available, and patients with severe CVD require surgery. PROX1 and FOXC2 are transcription factors that are required for the development of lymphatic and venous valves. We found that PROX1 and FOXC2 are expressed in a...

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Literature Corpus work: 6ac12211-fe4b-5da6-9818-adee90e8d130
DOI: 10.1101/2023.05.10.540284

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