Article

FOXC1 and FOXC2 maintain mitral valve endothelial cell junctions, extracellular matrix, and lymphatic vessels to prevent myxomatous degeneration

2023-08-30

Abstract excerpt

<h4>Background</h4> Mitral valve (MV) disease including myxomatous degeneration is the most common form of valvular heart disease with an age-dependent frequency. Genetic evidence indicates mutations of the transcription factor FOXC1 are associated with MV defects, including mitral valve regurgitation. In this study, we sought to determine whether murine Foxc1 and its closely related factor, Foxc2 , are requir...

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Literature Corpus work: d5df3d6d-1af2-54dd-bbe5-48dc4d5b3c7b
DOI: 10.1101/2023.08.30.555455

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