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Developmental pathways and endothelial to mesenchymal transition in canine myxomatous mitral valve disease

12 Aug 2015

Abstract excerpt

Epithelial to mesenchymal transition (EMT) and the cardiovascular equivalent, endothelial to mesenchymal transition (EndoMT), contribute to a range of chronic degenerative diseases and cancer metastasis. Chronic valvulopathies exhibit some features of EndoMT and activation of developmental signalling pathways, such as osteogenesis and chondrogenesis, expression of cell differentiation markers, basement membrane...

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PMID: 26586213
DOI: 10.1016/j.tvjl.2015.08.011

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