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Article

Macrophage Transitions in Heart Valve Development and Myxomatous Valve Disease.

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2018

Hulin Alexia, Anstine Lindsey J, Kim Andrew J, Potter Sarah J, DeFalco Tony, Lincoln Joy, Yutzey Katherine E

Abstract excerpt

OBJECTIVE: Hematopoietic-derived cells have been reported in heart valves but remain poorly characterized. Interestingly, recent studies reveal infiltration of leukocytes and increased macrophages in human myxomatous mitral valves. Nevertheless, timing and contribution of macrophages in normal valves and myxomatous valve disease are still unknown. The objective is to characterize leukocytes during postnatal heart...

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Identifiers

PMID: 29348122
DOI: 10.1161/ATVBAHA.117.310667
PMCID: PMC5823761

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CCR2

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