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Article

FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2024

Tan Can, Ge Zhi-Dong, Kurup Shreya, Dyakiv Yaryna, Liu Ting, Muller William A, Kume Tsutomu

Abstract excerpt

BACKGROUND: Mitral valve (MV) disease including myxomatous degeneration is the most common form of valvular heart disease with an age-dependent frequency. Genetic evidence indicates that mutations of the human transcription factor FOXC1 are associated with MV defects, including MV regurgitation. In this study, we sought to determine whether murine Foxc1 and its closely related factor, Foxc2, are required in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38989578
DOI: 10.1161/ATVBAHA.124.320316
PMCID: PMC11335087

Genes

FOXC1
FOXC2
PROX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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