Article

Prodromal Elevation of DNA Damage and Cell Cycle Biomarkers HRAS and CHEK2 in Amyotrophic Lateral Sclerosis

2025-12-11

Abstract excerpt

<title>Abstract</title> <p>Background: Pre-symptomatic biomarkers that reflect upstream pathogenic processes in amyotrophic lateral sclerosis (ALS) are urgently needed to enable earlier diagnosis and trial enrichment. <h4>Methods:</h4> Using longitudinal plasma proteomics from the UK Biobank Pharma Proteomics Project, we analyzed pre-diagnostic samples from 23 individuals who later developed motor neuron disease...

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Literature Corpus work: 6aaa6b7b-9ea0-500d-9349-e0504409491e
DOI: 10.21203/rs.3.rs-8328706/v1

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