Article

Predicting Phenoconversion to Clinically Manifest ALS: Results of a Large-Scale Proteomic Study

2025-12-08

Abstract excerpt

<h4>ABSTRACT</h4> The study of pre-symptomatic amyotrophic lateral sclerosis (ALS) and the design of disease prevention trials are greatly hampered by our inability to predict which unaffected carriers of ALS-associated pathogenic variants will phenoconvert to clinically manifest disease, and when. In this longitudinal Olink Explore high-throughput proteomic study, 516 serially collected plasma samples from 33 ph...

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Literature Corpus work: 128992d8-591a-50d5-8b27-be5d561c66ab
DOI: 10.64898/2025.12.06.25341403

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