Article

Dissociating cognitive compensation from cognitive deficit in neurodegenerative diseases: the model of premanifest Huntington’s disease mutation carriers

2023-12-13

Abstract excerpt

<title>Abstract</title> <p>Cognitive reserve is the ability to actively cope with brain deterioration and delay cognitive decline in neurodegenerative diseases. We combined computational modelling (drift diffusion models, DDMs) and neuroanatomical analysis using Huntington’s disease (HD) as a genetic model of neurodegenerative disease to study compensation in premanifest mutation carriers (preHDs). Twenty preHDs,...

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Literature Corpus work: 6a9e8336-36fb-5230-bb24-042dac8a7507
DOI: 10.21203/rs.3.rs-3187731/v1

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