Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prodromal Huntington disease as a model for functional compensation of early neurodegeneration.

PloS one - 1 Jan 2014

Malejko Kathrin, Weydt Patrick, Süßmuth Sigurd D, Grön Georg, Landwehrmeyer Bernhard G, Abler Birgit

Abstract excerpt

Functional compensation demonstrated as mechanism to offset neuronal loss in early Alzheimer disease may also occur in other adult-onset neurodegenerative diseases, particularly Huntington disease (HD) with its genetic determination and gradual changes in structural integrity. In HD, neurodegeneration typically initiates in the dorsal striatum, successively affecting ventral striatal areas. Investigating carriers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Huntington Disease
Share to Image Processing, Computer-Assisted

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Imaging

Share to Mutation

Share to Prefrontal Cortex

Share to Prodromal Symptoms

Source

Open in PubMed Open full text

Identifiers

PMID: 25541992
DOI: 10.1371/journal.pone.0114569
PMCID: PMC4277279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prodromal Huntington disease as a model for functional compensation of early neurodegeneration.PMID 25541992Read ↗

The cognitive burden in Huntington's disease: pathology, phenotype, and mechanisms of compensation.Semantic proximity Read ↗

Attentional compensation in neurodegenerative diseases: the model of premanifest Huntington’s disease mutation carriersSemantic proximity Read ↗

Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.Semantic proximity Read ↗

Neuroimaging as a tool to study the sources of phenotypic heterogeneity in Huntington's disease.Semantic proximity Read ↗

Investigating altered limbic reward system in Huntington's Disease: Implications for apathySemantic proximity Read ↗

Huntingtonʼs diseaseSemantic proximity Read ↗

Dissociating cognitive compensation from cognitive deficit in neurodegenerative diseases: the model of premanifest Huntington’s disease mutation carriersSemantic proximity Read ↗

Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington’s diseaseSemantic proximity Read ↗

Molecular Imaging of Huntington's Disease.Semantic proximity Read ↗

Prefrontal cortex white matter tracts in prodromal Huntington disease.Semantic proximity Read ↗

[Functional imaging of cognitive processes in Huntington's disease and its presymptomatic mutation carriers].Semantic proximity Read ↗

Striatal and white matter predictors of estimated diagnosis for Huntington disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.