Article
Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data.
The Lancet. Neurology - 1 Jul 2013
Tabrizi Sarah J, Scahill Rachael I, Owen Gail, Durr Alexandra, Leavitt Blair R, Roos Raymund A, Borowsky Beth, Landwehrmeyer Bernhard, Frost Chris, Johnson Hans, Craufurd David, Reilmann Ralf, Stout Julie C, Langbehn Douglas R
Abstract excerpt
BACKGROUND: TRACK-HD is a multinational prospective observational study of Huntington's disease (HD) that examines clinical and biological findings of disease progression in individuals with premanifest HD (preHD) and early-stage HD. We aimed to describe phenotypic changes in these participants over 36 months and identify baseline predictors of progression. METHODS: Individuals without HD but carrying the mutant...
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