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A Computational Cognitive Biomarker for Early-Stage Huntington’s Disease

12 Feb 2016

Abstract excerpt

Huntington's disease (HD) is genetically determined but with variability in symptom onset, leading to uncertainty as to when pharmacological intervention should be initiated. Here we take a computational approach based on neurocognitive phenotyping, computational modeling, and classification, in an effort to provide quantitative predictors of HD before symptom onset. A large sample of subjects-consisting of both...

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PMID: 26872129
DOI: 10.1371/journal.pone.0148409

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