Article

Dynamic thermodynamic-informational entropic relationship (TIER) models of selective vulnerability to neurodegeneration

2026-04-11

Abstract excerpt

BACKGROUND: Neurodegenerative diseases share selective vulnerability patterns suggesting common physical mechanisms. We apply unified mechanics theory to neural systems, predicting that brain regions accumulate structural damage proportional to computational workload. METHODS: We simulated a hierarchical neural network implementing relationships between mechanical work (W = F * D), proportional thermodynamic entro...

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Literature Corpus work: e41e8c1e-d029-5567-8696-d179e919015e
DOI: 10.64898/2026.04.08.714596

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