Article
The cognitive burden in Huntington's disease: pathology, phenotype, and mechanisms of compensation.
Movement disorders : official journal of the Movement Disorder Society - 15 Apr 2014
Papoutsi Marina, Labuschagne Izelle, Tabrizi Sarah J, Stout Julie C
Abstract excerpt
Huntington's disease (HD) is an inherited autosomal dominant neurodegenerative disorder. The most prominent sign of HD is the presence of involuntary motor movements. However, HD is also characterized by marked cognitive decline, which often precedes the onset of motor symptoms and is generally considered to be more debilitating to the patients and their families, compared to motor symptoms. Cognitive decline is...
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