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Conserved Epigenetic Programming and Enhanced Heme Metabolism Drive Memory B Cell Reactivation

24 Feb 2021

Abstract excerpt

Memory B cells (MBCs) have enhanced capabilities to differentiate to plasma cells and generate a rapid burst of Abs upon secondary stimulation. To determine if MBCs harbor an epigenetic landscape that contributes to increased differentiation potential, we derived the chromatin accessibility and transcriptomes of influenza-specific IgM and IgG MBCs compared with naive cells. MBCs possessed an accessible chromatin...

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PMID: 33627377
DOI: 10.4049/jimmunol.2000551

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