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Article

Quantitative Activity Profile and Context Dependence of All Human 5' Splice Sites.

Molecular cell - 20 Sept 2018

Wong Mandy S, Kinney Justin B, Krainer Adrian R

Abstract excerpt

Pre-mRNA splicing is an essential step in the expression of most human genes. Mutations at the 5' splice site (5'ss) frequently cause defective splicing and disease due to interference with the initial recognition of the exon-intron boundary by U1 small nuclear ribonucleoprotein (snRNP), a component of the spliceosome. Here, we use a massively parallel splicing assay (MPSA) in human cells to quantify the activity...

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Share to Genes, BRCA2
Share to Ribonucleoprotein, U1 Small Nuclear
Share to RNA, Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30174293
DOI: 10.1016/j.molcel.2018.07.033
PMCID: PMC6179149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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