Article

Broad variation in response of individual introns to splicing inhibitors in a humanized yeast strain

2023-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Intron branch point (BP) recognition by the U2 snRNP is a critical step of splicing, vulnerable to recurrent cancer mutations and bacterial natural product inhibitors. The BP binds a conserved pocket in the SF3B1 (human) or Hsh155 (yeast) U2 snRNP protein. Amino acids that line this pocket affect binding of splicing inhibitors like Pladienolide-B (Plad-B), such that organisms differ in their sen...

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Literature Corpus work: fc64de5e-bc9f-5ac3-a718-7f2a601b2fa5
DOI: 10.1101/2023.10.05.560965

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