Article

TRAIL orchestrates ThINKK-induced NK cell cytotoxicity against childhood acute lymphoblastic leukemia

2025-11-13

Abstract excerpt

<h4>Background</h4> Therapeutic Inducers of Natural Killer cell Killing (ThINKK) represent a novel class of immunotherapy designed to enhance the graft-versus-leukemia effect of hematopoietic stem cell transplantation in pediatric patients with high-risk or relapse leukemia. Our previous work identified high expression of TRAIL as a key signature of Natural Killer (NK) cell stimulation by ThINKK. In this study, w...

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Literature Corpus work: 6a6c9ea1-177b-5e00-a7b5-a28b3d2a6155
DOI: 10.1101/2025.11.12.687655

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