Article
TRAIL-mediated killing of acute lymphoblastic leukemia by plasmacytoid dendritic cell-activated natural killer cells.
Oncotarget - 6 Oct 2015
Lelaidier Martin, Dìaz-Rodriguez Yildian, Cordeau Martine, Cordeiro Paulo, Haddad Elie, Herblot Sabine, Duval Michel
Abstract excerpt
Acute lymphoblastic leukemia (ALL) still frequently recurs after hematopoietic stem cell transplantation (HSCT), underscoring the need to improve the graft-versus-leukemia (GvL) effect. Natural killer (NK) cells reconstitute in the first months following HSCT when leukemia burden is at its lowest, but ALL cells have been shown to be resistant to NK cell-mediated killing. We show here that this resistance is...
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