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AKR1C enzymes sustain therapy resistance in paediatric T-ALL

6 Mar 2018

Abstract excerpt

BACKGROUND: Despite chemotherapy intensification, a subgroup of high-risk paediatric T-cell acute lymphoblastic leukemia (T-ALL) patients still experience treatment failure. In this context, we hypothesised that therapy resistance in T-ALL might involve aldo-keto reductase 1C (AKR1C) enzymes as previously reported for solid tumors. METHODS: Expression of NRF2-AKR1C signaling components has been analysed in...

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PMID: 29515258
DOI: 10.1038/s41416-018-0014-0

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