Article

HDAC3 inhibition as a therapeutic strategy in T-cell acute lymphoblastic leukemia via the TYK2-STAT1-BCL2 signaling pathway

2025-03-01

Abstract excerpt

<h4>Introduction</h4> Few advances have been made in treating T-cell acute lymphoblastic leukemia (T-ALL). Approaches targeting histone deacetylases (HDAC) have not been thoroughly investigated in T-ALL. However, the underlying molecular mechanism of HDAC inhibition remains to be fully elucidated. <h4>Objectives</h4> The study aimed to evaluate the clinical outcome of chidamide (an oral selective HDAC inhibitor fo...

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Literature Corpus work: 4646b49f-a47c-5320-adb3-9882b0c996f0
DOI: 10.1101/2025.02.27.25322993

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