Article

Reduced reproductive success is associated with selective constraint on human genes

2020-05-28

Abstract excerpt

<h4>Summary</h4> Genome-wide sequencing of human populations has revealed substantial variation among genes in the intensity of purifying selection acting on damaging genetic variants 1 . While genes under the strongest selective constraint are highly enriched for associations with Mendelian disorders, most of these genes are not associated with disease and therefore the nature of the selection acting on them is...

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Literature Corpus work: 6a5a392b-0459-548e-a127-e61218a3a8b6
DOI: 10.1101/2020.05.26.116111

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