Article
Human testis-specific genes are under relaxed negative selection.
Molecular genetics and genomics : MGG - 1 Feb 2014
Pierron Denis, Razafindrazaka Harilanto, Rocher Christophe, Letellier Thierry, Grossman Lawrence I
Abstract excerpt
Recent studies have suggested that selective forces and constraints acting on genes varied during human evolution depending on the organ in which they are expressed. To gain insight into the evolution of organ determined negative selection forces, we compared the non-synonymous SNP diversity of genes expressed in different organs. Based on a HAPMAP dataset, we determined for each SNP its frequency in 11 human...
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