Article
Why do we get sick? Genetic evidence for evolutionary trade-offs between fertility, longevity, and disease
2025-06-20
Abstract excerpt
The persistence of genetic variants that increase susceptibility to complex diseases poses an evolutionary paradox: despite their detrimental health effects, these variants are not eliminated by natural selection. Life-history theory proposes that trade-offs and pleiotropic effects across fitness components may explain the evolutionary maintenance of disease-associated alleles. We hypothesize that certain disease-...
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Identifiers and source
- Literature Corpus work
- 01961ea4-3448-5bfa-8868-d82b73a6909d
- DOI
- 10.1101/2025.06.18.25329754