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Article

Reproductive fitness and genetic risk of psychiatric disorders in the general population.

Nature communications - 13 Jun 2017

Mullins Niamh, Ingason Andrés, Porter Heather, Euesden Jack, Gillett Alexandra, Ólafsson Sigurgeir, Gudbjartsson Daniel F, Lewis Cathryn M, Sigurdsson Engilbert, Saemundsen Evald, Gudmundsson Ólafur Ó, Frigge Michael L, Kong Augustine, Helgason Agnar, Walters G Bragi, Gustafsson Omar, Stefansson Hreinn, Stefansson Kari

Abstract excerpt

The persistence of common, heritable psychiatric disorders that reduce reproductive fitness is an evolutionary paradox. Here, we investigate the selection pressures on sequence variants that predispose to schizophrenia, autism, bipolar disorder, major depression and attention deficit hyperactivity disorder (ADHD) using genomic data from 150,656 Icelanders, excluding those diagnosed with these psychiatric...

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Identifiers

PMID: 28607503
DOI: 10.1038/ncomms15833
PMCID: PMC5474730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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