Article
Ultra-rare disruptive and damaging mutations influence educational attainment in the general population.
Nature neuroscience - 1 Dec 2016
Ganna Andrea, Genovese Giulio, Howrigan Daniel P, Byrnes Andrea, Kurki Mitja, Zekavat Seyedeh M, Whelan Christopher W, Kals Mart, Nivard Michel G, Bloemendal Alex, Bloom Jonathan M, Goldstein Jacqueline I, Poterba Timothy, Seed Cotton, Handsaker Robert E, Natarajan Pradeep, Mägi Reedik, Gage Diane, Robinson Elise B, Metspalu Andres, Salomaa Veikko, Suvisaari Jaana, Purcell Shaun M, Sklar Pamela, Kathiresan Sekar, Daly Mark J, McCarroll Steven A, Sullivan Patrick F, Palotie Aarno, Esko Tõnu, Hultman Christina, Neale Benjamin M
Abstract excerpt
Disruptive, damaging ultra-rare variants in highly constrained genes are enriched in individuals with neurodevelopmental disorders. In the general population, this class of variants was associated with a decrease in years of education (YOE). This effect was stronger among highly brain-expressed genes and explained more YOE variance than pathogenic copy number variation but less than common variants. Disruptive,...
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