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Identification of 370 genetic loci for age at first sex and birth linked to externalising behaviour

2020-05-07

Abstract excerpt

Age at first sexual intercourse (AFS) and age at first birth (AFB) have implications for health and evolutionary fitness. In the largest genome-wide association study to date (AFS, N=387,338; AFB, N=542,901), we identify 370 independent signals, 11 sex-specific, with a 5-6% polygenic score (PGS) prediction. Heritability of AFB shifted from 9% [CI=4-14] for women born in 1940 to 22% [CI=19-25] in 1965. Signals are...

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Literature Corpus work
f98cabeb-9c21-5e28-87b3-fb7dbb213090
DOI
10.1101/2020.05.06.081273
Open publication

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Identification of 370 genetic loci for age at first sex and birth linked to externalising behaviourDOI 10.1101/2020.05.06.081273
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