Article
Evidence for the role of selection for reproductively advantageous alleles in human aging
2023-04-14
Abstract excerpt
<h4>ABSTRACT</h4> The antagonistic pleiotropy hypothesis posits that natural selection for pleiotropic mutations that confer earlier or more reproduction but impair the post-reproductive life causes aging. This hypothesis of the evolutionary origin of aging is supported by case studies but lacks unambiguous genomic evidence. Here we genomically test this hypothesis using the genotypes, reproductive phenotypes, an...
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Identifiers and source
- Literature Corpus work
- 54e0517d-e37f-54e1-8916-123772bd753e
- DOI
- 10.1101/2023.04.13.536806