Article

The Duality of Adiponectin and the Role of Sex in Atherosclerosis

2023-05-24

Abstract excerpt

Adiponectin, a hormone highly abundant in circulation, has many beneficial effects in atherosclerosis; however, gene deficiency of this hormone or its receptor have shown detrimental effects on plaque burden in mice. Our objective was to understand the role of sex and aging in the effects of adiponectin deficiency on plaque content, inflammation, and the mechanisms regulating the phenotype of adipoq -/- vascular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6a4c2a71-f0dd-5eca-b336-d47ddbab3de4
DOI: 10.1101/2023.05.23.541764

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Duality of Adiponectin and the Role of Sex in AtherosclerosisDOI 10.1101/2023.05.23.541764Read

AKT Mediates Adiponectin-Dependent Regulation of VSMC Phenotype.Semantic proximity Read

Re-evaluating the Impact of Biological Sex on Atherosclerosis in Apoe <sup>−/−</sup> and Ldlr <sup>−/−</sup> miceSemantic proximity Read

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease.Semantic proximity Read

β-Sarcoglycan Deficiency Reduces Atherosclerotic Plaque Development in ApoE-Null Mice.Semantic proximity Read

C/EBPβ activation in vascular smooth muscle cells promotes hyperlipidemia-induced phenotypic transition and arterial stiffness.Semantic proximity Read

Sex Differences in Protein Biomarkers and Measures of Fat DistributionSemantic proximity Read

Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of Low Density Lipoprotein Related Protein 1 (LRP1)Semantic proximity Read

Cardiovascular Benefits of Menopause Hormone Treatment is Age-DependentSemantic proximity Read

Investigating the Effects of Sex Hormones on Macrophage PolarizationSemantic proximity Read

Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.Semantic proximity Read

Unravelling the adiponectin paradox: novel roles of adiponectin in the regulation of cardiovascular diseaseSemantic proximity Read

Sex-specific cardioprotective role of miR-30a-5p through estrogen-dependent mechanisms in a mouse model of heart failure.Semantic proximity Read