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Article

Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice.

PloS one - 1 Jan 2013

Lindgren Anna, Levin Malin, Rodrigo Blomqvist Sandra, Wikström Johannes, Ahnmark Andrea, Mogensen Christina, Böttcher Gerhard, Bohlooly-Y Mohammad, Borén Jan, Gan Li-Ming, Lindén Daniel

Abstract excerpt

Adiponectin has been shown to have beneficial cardiovascular effects and to signal through the adiponectin receptors, AdipoR1 and AdipoR2. The original aim of this study was to investigate the effect of combined AdipoR1 and AdipoR2 deficiency (AdipoR1(-/-)AdipoR2(-/-)) on atherosclerosis. However, we made the interesting observation that AdipoR1(-/-) AdipoR2(-/-) leads to embryonic lethality demonstrating the...

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Source

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Identifiers

PMID: 24324556
DOI: 10.1371/journal.pone.0080330
PMCID: PMC3855811

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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