Article

Tissue-Resident Macrophage and Dendritic Cell Cooperation Drives Type I IFN Immunity to Enteroviruses in the Liver

2025-08-12

Abstract excerpt

Enteroviruses are major causes of neonatal morbidity and mortality, with echovirus infections commonly associated with severe disease, including acute liver failure. The human neonatal Fc receptor (hFcRn) is the primary receptor for echoviruses, and its expression is required for infection of the liver in mouse models. While type I interferons (IFNs) are known to protect against echovirus-induced disease, the spec...

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Literature Corpus work: 6a255a74-6dcf-5bf6-a6d8-cd9db8567ea4
DOI: 10.1101/2025.08.12.669977

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