Article

TLR3 Expression in Villus-Like Enterocytes Drives IFN-III Responses to Enteroviruses

2026-04-03

Abstract excerpt

Enteroviruses initiate infection at the intestinal epithelium but can spread systemically to cause severe disease. Although both MDA5 and TLR3 have been implicated in enterovirus sensing, the mechanisms by which the intestinal epithelium detects these viruses remain poorly defined. To address this, we infected human intestinal organoids (enteroids) with echovirus 11 (E11) and compared responses in models different...

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Literature Corpus work: 291b8002-2e90-549c-a85c-27b72fd36dd4
DOI: 10.64898/2026.04.01.715830

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