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The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor

7 Aug 2024

Abstract excerpt

Arteriviruses infect a variety of mammalian hosts, but the receptors used by these viruses to enter cells are poorly understood. We identified the neonatal Fc receptor (FcRn) as an important pro-viral host factor via comparative genome-wide CRISPR-knockout screens with multiple arteriviruses. Using a panel of cell lines and divergent arteriviruses, we demonstrate that FcRn is required for the entry step of...

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PMID: 39112502
DOI: 10.1038/s41467-024-51142-x

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