Article

Ebola virus infection induces a type I interferon response and the shutdown of key liver functions in human iPSC-derived hepatocytes

2021-03-26

Abstract excerpt

<title>Abstract</title> <p>Liver damage and an exacerbated inflammatory response are hallmarks of Ebola virus (EBOV) infection. Little is known about the intrinsic response to infection in human hepatocytes and their contribution to the observed inflammatory response. Here, we present an iPSC-derived hepatocyte platform to define the hepato-intrinsic response to EBOV infection. Transcriptomics analysis revealed a...

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Literature Corpus work: 598627f9-c322-5899-af28-89f80f7b94b1
DOI: 10.21203/rs.3.rs-346554/v1

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