Article

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis

2021-12-09

Abstract excerpt

<h4>ABSTRACT</h4> A significant fraction of sudden death in children and young adults is due to myocarditis, an inflammatory disease of the heart, most often caused by viral infection. Here we used integrated single-cell and spatial transcriptomics to create a high-resolution, spatially resolved map of reovirus-induced myocarditis in neonatal murine hearts. We assayed hearts collected at three timepoints after re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 523c6513-7a17-5118-b07f-6eee7f8f9626
DOI: 10.1101/2021.12.07.471659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditisDOI 10.1101/2021.12.07.471659Read

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditisSemantic proximity Read

Tissue transcriptomics of endomyocardial biopsies reveals widespread molecular perturbations independent of leukocyte-rich foci in human myocarditisSemantic proximity Read

Dissecting the cellular landscape and transcriptome network in viral myocarditis by single-cell RNA sequencingSemantic proximity Read

Spatial transcriptomics reveals layered immune-metabolic architecture of giant cell myocarditisSemantic proximity Read

Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditisSemantic proximity Read

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heartSemantic proximity Read

Single-Cell RNA Sequencing Reveals the Altered Landscape of Immune Cells in Immune Checkpoint Inhibitor Related MyocarditisSemantic proximity Read

Single cell transcriptional profiling reveals cellular diversity, communication, and sexual dimorphism in the mouse heartSemantic proximity Read

Deciphering Immune Complexity: Single-Cell Insights into Autoimmune Myocarditis ProgressionSemantic proximity Read

Macrophage-derived SPP1 exacerbate myocardial injury by interacting with fibroblasts in viral myocarditisSemantic proximity Read

Cross-species single-cell RNA-seq analysis reveals disparate and conserved cardiac and extracardiac inflammatory responses upon heart injurySemantic proximity Read

Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditisSemantic proximity Read