Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors

Abstract excerpt

<title>Abstract</title> <p>More than half of human malignant tumors harbor TP53 gene mutations, most of which are point mutations within the DNA-binding domain of TP53, resulting in mutant p53 (mutp53) protein stabilization and accumulation in the cell and enhanced tumor progression. Depletion of mutp53 through the autophagy or proteasome pathway is considered the most direct strategy to target mutp53 for tumor t...

Topics

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• Autophagy
• Cell Line, Tumor
• Mice
• Mitochondria
• Mutant Proteins
• Mutation
• Proteasome Endopeptidase Complex
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

6a097611-132b-5752-9219-660bbf1454a9

DOI

10.21203/rs.3.rs-1039913/v1