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Article

Proteasomal and autophagy-mediated degradation of mutp53 proteins through mitochondria-targeting aggregation-induced-emission materials.

Acta biomaterialia - 15 Sept 2022

Wang Meimei, Yang Zhenyu, Song Yang, Wei Pengfei, Ishiwme Nestor, Wang Liansheng, Zhang Hao, Jing Manman, Gao Meng, Wen Longping, Zhang Yunjiao

Abstract excerpt

Close to half of human cancers harbor point mutations in the tumor-suppressor p53 gene, giving rise to the cellular accumulation of mutant p53 (mutp53) proteins with novel neomorphic gain-of-function (GOF) properties. The destruction of mutp53 proteins through either autophagic or proteasomal degradation is a viable strategy for the targeted therapy of p53-mutated cancers. Several nanomaterials, including...

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PMID: 35931280
DOI: 10.1016/j.actbio.2022.07.057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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