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The Role of p53 in Nanoparticle-Based Therapy for Cancer

8 Dec 2023

Abstract excerpt

p53 is arguably one of the most important tumor suppressor genes in humans. Due to the paramount importance of p53 in the onset of cell cycle arrest and apoptosis, the p53 gene is found either silenced or mutated in the vast majority of cancers. Furthermore, activated wild-type p53 exhibits a strong bystander effect, thereby activating apoptosis in surrounding cells without being physically present there. For...

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PMID: 38132123
DOI: 10.3390/cells12242803

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