Article
Glutathionylation-dependent proteasomal degradation of wide-spectrum mutant p53 proteins by engineered zeolitic imidazolate framework-8.
Biomaterials - 1 Apr 2021
Zhang Yunjiao, Huang Xiaowan, Wang Liansheng, Cao Cong, Zhang Hao, Wei Pengfei, Ding He, Song Yang, Chen Ziying, Qian Jieying, Zhong Suqin, Liu Zefeng, Wang Meimei, Zhang Wenbin, Jiang Wenwei, Zeng Jie, Yao Guangyu, Wen Long-Ping
Abstract excerpt
Point mutations within the DNA-binding domain of the TP53 gene occur in a significant percentage of human cancer, leading to cellular accumulation of highly stabilized mutant p53 proteins (mutp53) with tumor-promoting properties. Depletion of mutp53, through inducing either autophagic or proteasomal degradation, is an attractive strategy for the therapy of p53-mutated cancer, but the currently-known degradation...
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