Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selenide-Bridged Redox-Responsive Nanoparticles: A Synergistic Strategy to Overcome p53 Mutation-Mediated Drug Resistance in Gastric Cancer.

ACS nano - 4 Aug 2026

Tang Cuiman, Wang Zhongjuan, Liu Yankun, Liu Zhicun, Zhu Wen, Zhao Xiuhua

Abstract excerpt

Selenium deficiency is linked to gastric cancer, and p53 mutant tumors often acquire chemoresistance. To address this, we designed a camptothecin (CPT) dimeric prodrug with a hybrid -S-Se-S- linker (CPT-S-Se-S-CPT). It self-assembles into uniform nanoparticles (SSeSCPT NPs) with dual redox-responsive release triggered by glutathione and reactive oxygen species. Selenium plays dual synergistic roles: it enhances...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Camptothecin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Nanoparticles

Share to Oxidation-Reduction

Share to Prodrugs

Share to Selenium

Share to Stomach Neoplasms

Source

Identifiers

PMID: 42478957
DOI: 10.1021/acsnano.6c06164

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selenide-Bridged Redox-Responsive Nanoparticles: A Synergistic Strategy to Overcome p53 Mutation-Mediated Drug Resistance in Gastric Cancer.PMID 42478957Read ↗

Nanomedicine Strategies to Overcome Multi-Drug Resistance in Cancer: Innovations in Targeted Delivery, Tumor Microenvironment Modulation and Synergistic TherapiesSemantic proximity Read ↗

Nanotechnology-integrated ferroptosis inducers: a sharp sword against tumor drug resistanceSemantic proximity Read ↗

Vitamin - Conjugated Metallic Nanoparticles: Applications for Antimicrobial and Anti-Cancer Drug DeliverySemantic proximity Read ↗

The application of nanoparticles in diagnosis and theranostics of gastric cancer.Semantic proximity Read ↗

Self-amplifying ROS-sensitive SN38 Dimeric Prodrug nanoparticles for Combined Chemotherapy and Ferroptosis in Cancer TreatmentSemantic proximity Read ↗

Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistanceSemantic proximity Read ↗

A super-assembled synergistically nanoplatform AP@ZIF-8 Pt for hepatocarcinoma therapySemantic proximity Read ↗

Disulfide bond-rich Nano-Silica for High-Efficiency cancer immunotherapy using synergistic endoplasmic reticulum stress cooperated mitochondrial dysfunctionSemantic proximity Read ↗

Adavosertib-encapsulated metal-organic frameworks for p53-mutated gallbladder cancer treatment via synthetic lethality.Semantic proximity Read ↗

Mechanisms of the Cytotoxic Effect of Selenium Nanoparticles in Different Human Cancer Cell LinesSemantic proximity Read ↗

Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer.Semantic proximity Read ↗

Pro-ATO/Allicin Liposomes for Dual-Pathway Targeting of p53-Mutant Tumors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.