Article
Crizotinib Nanomicelles Synergize with Chemotherapy through Inducing Proteasomal Degradation of Mutp53 Proteins.
ACS applied materials & interfaces - 11 Jan 2023
Yi Tianxiang, Qian Jieying, Ye Yayi, Zhang Hao, Jin Xin, Wang Meimei, Yang Zhenyu, Zhang Wang, Wen Longping, Zhang Yunjiao
Abstract excerpt
TP53 missense mutations that express highly stabilized mutant p53 protein (mutp53) driving tumorigenesis have been witnessed in a considerable percentage of human cancers. The attempt to induce degradation of mutp53 has thus been an attractive strategy to realize precise antitumor therapy, but currently, there has been no FDA-approved medication for mutp53 cancer. Herein, we discovered a small molecule compound...
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