Article

PRC2 complex subunit JARID2 regulates embryonic pituitary stem cell differentiation to the POMC lineage

2026-06-15

Abstract excerpt

The pituitary is essential for growth, fertility, and stress response. Pituitary development is defined by transcription factor cascades, but how chromatin landscapes influence it remains elusive. JARID2 is a subunit of polycomb repressive complex 2 repressing transcription by depositing trimethylation on histone 3 lysine 27 (H3K27me3). Here, we established that H3K27me3 levels increase with differentiation in ant...

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Literature Corpus work: 6a079468-18fc-522c-81e9-0874e88144d3
DOI: 10.64898/2026.06.11.731685

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